You are here:

Vagus Nerve Stimulation (VNS) Therapy

Published on


Vagus Nerve Stimulation (VNS) Therapy

Vagus Nerve Stimulation therapy is a treatment for epilepsy that involves a stimulator (or 'pulse generator') which is connected, inside the body, to the left vagus nerve in the neck. The stimulator sends regular, mild electrical stimulations through this nerve to help calm down the irregular electrical brain activity that leads to seizures.

There are several ways to treat epilepsy. How well each treatment works varies from one person to another. Vagus nerve stimulation therapy is a form of treatment for people with epilepsy whose seizures are not controlled with medication.


What are the vagus nerves?

The vagus nerves are a pair of nerves that start in the brain and run through the body. They carry messages between the brain and the body.

What is VNS therapy and how does it work?

Vagus nerve stimulation (VNS) therapy is a treatment for epilepsy that involves a stimulator (or 'pulse generator') which is connected, inside the body, to the left vagus nerve in the neck. The stimulator sends regular, mild electrical stimulations through this nerve to help calm down the irregular electrical brain activity that leads to seizures.

What is the aim of VNS therapy?

VNS therapy aims to reduce the number, length, and severity of seizures. For some people, their seizures become much less frequent, for some it may reduce their seizures a little, and for others it has no effect. VNS therapy may reduce the length or intensity of seizures but this does not happen for everyone. It may also reduce the time it takes to recover after a seizure. It is possible to completely stop some seizures but it does not ‘cure’ epilepsy.

The effect of VNS therapy may not happen straightaway; it can take up to a year for it to have an effect on someone's seizures. It is used alongside anti-seizure medications (ASMs) not instead of them. However, if VNS therapy works, it may be possible to reduce a person’s ASMs over time.

Can I be considered for VNS therapy?

VNS therapy is usually considered if you have tried a number of ASMs which have not fully controlled your seizures, and if you are not suitable for, or do not want to have, brain surgery.

People who are considering VNS therapy will usually be given information about VNS from their neurologist or epilepsy specialist nurse.

What is the stimulator like?

The stimulator is a bit like a heart pacemaker. It is implanted (placed) under the skin in the upper chest (under the left collar bone) during a small operation under general anaesthetic.

Because of the size of the stimulator there will be a small lump where it lies, and a small scar where it was put in. A lead connects the stimulator in the chest to the vagus nerve in the left side of the neck. Because the electrodes are coiled around the nerve in the neck, there will also be a small scar where they are inserted, usually in the fold of the neck.

How does the stimulator work?

The stimulator is usually switched on within two weeks of it being implanted. The neurologist or nurse will programme the stimulator and set the amount (strength and length) of the electrical stimulation given. The amount of stimulation varies from person to person, but is usually started at a low level and slowly increased to a suitable level for each person. Usually it is set at 30 seconds of stimulation every five minutes through the day and night.

The stimulator has a battery inside it which can last up to five years. When the battery is low, the stimulator needs to be replaced, during an operation similar to the one when it was put in.

What can VNS therapy do if I have a seizure?

Some people have a warning or aura, which is a focal aware seizure, that tells them that they are going to have a further seizure. When this happens, a special magnet can be passed over the stimulator to give stronger stimulation for a slightly longer period of time. This may stop the aura from developing into another seizure, or may reduce how long it takes the person to recover after a seizure.

Keep the magnet close by - it can be worn on the wrist like a watch, on a belt, or attached to a wheelchair. For people who have no warning before a seizure, someone else could use the magnet for them when a seizure happens. The magnet can also be swiped over the VNS after a seizure and it may help with post seizure recovery.

Some people may experience an increase in heart rate during their seizures. The AspireSR® and  SenTiva® devices can pick up these changes and give automatic stimulation in a similar way to magnet stimulation.

Does VNS therapy have any side effects?

VNS therapy can cause side effects but usually only during the time that the nerve is being stimulated. Side effects may not happen for everyone but can include discomfort in the throat, a cough, difficulty swallowing, and a hoarse voice.

Side effects usually reduce over time and do not usually mean that the stimulator has to be switched off. If side effects are a problem, the neurologist or nurse can adjust the settings, or the magnet can be held over the stimulator for a few seconds to briefly stop the stimulation.

VNS therapy does not affect, and is not affected by, anti-seizure medication.

What about any other positive effects?

Some people feel that VNS therapy improves their mood, memory, or alertness, and may also help reduce depression or have a positive effect on their quality of life (overall wellbeing).

What happens if it does not work?

VNS therapy does not work for everyone. If there is no benefit received from VNS therapy, you and your specialist may consider having it switched off or removed. Even if VNS therapy has no effect on the seizures, it might have other positive effects (see previous question).

Can I have an MRI scan if I have VNS therapy?

If you have VNS therapy and need an MRI, it is important that everyone involved with the scan is aware, so that they can decide if the scan can be done safely.

VNS therapy is 'MRI conditional' meaning that, as long as certain precautions are followed, an MRI scan is possible on some areas of the body. Visit for more information.

X-rays and CT scans do not affect, and are not affected by, VNS therapy. This is because they do not produce enough radiation to cause damage to the stimulator. However, extra care may be needed, or the stimulator may need to be switched off for the scan, and turned back on again afterwards.

Can I use an induction hob?

VNS devices may be affected by the magnet in an induction hob. However, to affect the VNS device, the magnet in the induction hob would have to be directly over the VNS device itself. So you would have to be leaning your chest over and directly onto an induction hob for it to affect the VNS. In addition, the magnet in the induction hob would only disable VNS for the period of time it is held over the device - so usually relatively short time periods. It stops the usual stimulation from working temporarily, restarting once the magnet is not close to the VNS device.

Can I go through airport security?

At the airport, you can provide security officers with your VNS Therapy ID card, which explains that you have an implanted medical device. You can request a pat down check instead.

Further information

LivaNova (makers of the VNS therapy system) 

Visit for more information about VNS therapy for patients and carers, and for medical professionals. 

Original image by kind permission of LivaNova.

Information produced: August 2023

Brain scans

In order for a person to be suitable for surgery, it is necessary to confirm that seizures are arising from one part of the brain and that it is safe to remove this part. This requires many tests including MRI brain scans.

Taken from our 'VNS therapy' factsheet


We send monthly e-newsletters to keep you informed with tips for managing epilepsy, the latest news, inspirational stories, fundraising opportunities and further information from Epilepsy Society.

Read our privacy policy

It is always your choice as to whether you want to receive information from us. You may opt-out of our marketing communications by clicking the ‘unsubscribe’ link at the end of our marketing emails or through our unsubscribe number 01494 601 300.