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Neuroimaging

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Neuroimaging

"What gets me up in the morning is the ability to make new scientific advances and to apply them to people who one sees in the clinics. Real people with real problems. It is exciting to apply the latest scientific advances which allow us to be more precise and more specific. We can identify problems that we could not see before."

John Duncan is Professor of Neurology at UCL Queen Square Institute of Neurology, Consultant Neurologist at UCLH and Principal Investigator in Neuroimaging at Epilepsy Society.

Photo of the MRI team at Epilepsy Society

Overview

The Epilepsy Society MRI Unit, Chalfont St Peter, Buckinghamshire and is located in a dedicated building adjacent to the newly opened Epilepsy Society Research Centre. 

In 2019, there was a major upgrade to the Chalfont MR scanner to enable increase resolution, particularly of diffusion and functional MRI that show the nerve fibre connections in the brain and the parts of the brain that are critical for language and memory. 

MRI

Epilepsy Society's MRI Unit is key component of extensive collaborations with UCL, The greatly enhanced connectivity and the state of the art scan storage facility enables scan data to be accessible, with colleagues at other locations.

The acquisition of MRI data at The Chalfont Centre is crucial, as it is co-located with the Gowers Centre and outpatients and research MRI can be acquired at the same time as clinical MRI. Valuable image analysis is also carried out on MRI scans that are obtained  for clinical purposes, which is a fundamental tenet of the UCLH-UCL shared vision of having a Research Hospital. 

Our research areas

Optimising epilepsy surgery

Discover how the removal of the temporal part of the piriform cortex greatly increases the chances of seizure freedom after temporal lobe resection for temporal lobe epilepsy. 

Analysis of brain structure

Identifying focal abnormalities that underlie refractory epilepsy is crucial in the consideration of epilepsy surgery. 

Machine learning and quantitative MRI

We have created a multivariable AI based program to identify covert abnormalities in individuals who are considering surgery and validating this with the sites of seizure onset in individuals having intracranial EEG at NHNN. 

Functional MRI (fMRI)

In the last 20 years we have been using functional MRI (fMRI) at Epilepsy Society's Chalfont Centre to map where different functions such as language and vision occur in the brain.

Language

fMRI can show where in the brain language and memory is carried out. This enables us to predict the risks of surgery and lateralise language functions pre-surgically our next step is to use this information to design surgery that does not affect language.

Memory and brain function

Difficulties with language and memory are a significant issue in people with epilepsy. Epilepsy surgery may be a suitable treatment option in some people however in some there is worsening of language and memory functions that can significantly impact of quality of life.

Understanding the effects of medication and Pharmaco-fMRI

Adverse effects of epilepsy medication has a very negative effect on quality of life. Functional MRI (fMRI) can show the brain activation that underpin language and memory and thought.

Post-mortem MRI

Sudden unexpected death in epilepsy (SUDEP) is one of the top ten causes of premature death in the UK and sudden death is 24 times more likely to occur in people with epilepsy than the general population.  

Inflammation and blood brain imaging

Depression, is common in epilepsy. Brain inflammation occurs in epilepsy and depression. We will use novel MRI to demonstrate this brain inflammation that may give rise to seizures and depression so that we may identify effective therapies.

Peter Murkin Senior Radiographer

Research papers

We've compiled a summary of our latest research papers for you to read, written by our powerhouse multidisciplinary team who contribute to a wide ranging spectrum of epilepsy research. 

This includes PhD theses from the ES MRI Epilepsy Imaging Group.

These papers give you a snapshot of our teams clinical and research knowledge, which is helping us to further our understanding of people with epilepsy.

Teaching

Every March for the last 3 years Professor Matthias Koepp has organized the International League against Epilepsy Neuroimaging course, at Chalfont MRI  and Research Centre. This is very highly regarded internationally, with delegates coming from all over the world, and is always oversubscribed.

Case studies

Find out how the quality of life of people with epilepsy improved as a direct result of neuroimaging and subsequent surgery. 

Future look

In 2021 we will continue our current research priorities of imaging language and memory and the structural basis of these in epilepsy, and to visualize multimodal data in 3-dimensions for the optimization of epilepsy surgery. We will further link imaging data with genetics in the ENIGMA project.

We will set-up imaging of inflammation and break-down of the blood-brain-barrier in epilepsy, and will explore the effects of anti-epileptic drugs on the brain.

We will explore the possibility of using MRI as an adjunct to post-mortem examination of individuals who succumb to SUDEP, to try to better understand the causation of this tragedy. 

In the next 5 years, epilepsy imaging research will need access to a 7T MRI scanner, if we are to be globally competitive and to have this linked with a MEG facility using novel mobile MEG technology and PET.
 

Cool face

Reading brain scans through Artificial Intelligence

Researcher Baris Kanber explains how machine learning - or Artificial Intelligence - could enable more people with uncontrolled seizures to achieve seizure freedom.

How MRI has changed lives

Professor John Duncan explains the difference that MRI has made to the diagnosis and treatment of epilepsy over more than two decades and the difference it has made to people's lives.

Funding

Epilepsy Society supports the MRI scanner and the premises and pays the salaries of radiographers, administration and part of Prof MJ Koepp’s and Dr M Sidhu’s salaries. Other salaries are supported by Epilepsy Society (Sobell Foundation), UCL, NHS, NIHR senior investigator award and NIHR Biomedical Research Centre, Wellcome Trust, MRC, Epilepsy Research UK, Newton Foundation.

Contact us

Epilepsy Society MRI Unit, Chesham Lane, Chalfont St Peter, SL9 0RJ
Tel: +44 (0)1494 601360 - Fax: +44 (0)1494 875945
 

Genomics

Read how we are working to understand the genetic architecture of each individual person's epilepsy through our world leading genomics research programme.